Sentence examples for optimize compound from inspiring English sources

Overall, this study shows that this conformal gain-cost driven method is a promising approach to optimize compound selection in screening programs in terms of optimising the gain.

Attempts to optimize compound separation failed to provide baseline separation in the UV chromatograms, using either the BEH C18 or a number of other columns such as CSH (Charged Surface Hybrid) and HSS (High Strength Silica).

Drug discovery is one of the most challenging applied sciences due to the complexity of disease biology and the requirement to simultaneously optimize compound potency, selectivity, pharmacokinetics, physical properties, and safety in order to deliver an effective therapeutic agent.

The crystal structure of human butyrylcholinesterase in complex with compound 8g is also solved, which suggests ways to further optimize compounds featuring the 8-hydroxyquinoline scaffold.

Simply due to their vast number, the efficacies of all compounds cannot be studied; thus, a robust system to prioritize and optimize compounds must be adopted.

Moreover, the use of prion-infected mice allowed efficient testing of a large number of compounds in vivo in an authentic disease model and, thus, to optimize compounds in regard to in vivo efficacy while balancing the in vitro efficacy in an unprecedented way.

The mechanism of OASP compound flooding was discussed to provide a theoretical basis for optimizing compound flooding systems for high-temperature heterogeneous reservoirs.

In addition, we suggest that such an objective binding site map, which encompasses unliganded cavities, will also be useful for optimizing compound screening collections towards a more complete chemical coverage of binding site space.

Optimized compound 27 has an excellent off-target activity profile in erythrocyte lysis and HepG2 assays and is stable in human plasma.

General SAR has been established for the substituents at positions 1 and 2, as well as the importance of the ethylene group and its attachment to position 5. Optimized compounds are much more potent than SAHA in both enzymatic and cellular assays.

Moreover it constitutes an attractive technology for drug discovery programs, for high content, high throughput screening assays, to assess the potency of new hits and optimize lead compounds, whilst also serving to characterize drugs developed through rational design.