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Further work with animal models of sarcoma and ultimately clinical studies needs to be done to evaluate and optimize combinations of Nutlin and current chemotherapies.
Thus, the use of stage specific factors at Fab-7 could reflect a need to optimize combinations with other nearby BX-C boundaries or the Abdominal-B promoter (Kyrchanova et al., 2008b, 2011).
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Finally, we highlight the utility of mouse models for BRCA1-mutated breast cancer to optimize (combination) therapy and to understand drug resistance.
Potential public health applications will need to optimize combination of these factors and cost of screening.
Our study provides important leads to optimize combination treatment in the clinical setting.
To optimize combination therapy of cancers, next-generation nanomedicines are developed to co-deliver multiple drugs or accommodate multiple therapeutic modalities.
Studies on in vivo breast cancer models with alterations in the PI3K pathway should increase our understanding of this complex but fascinating signaling network, test the validity of this speculation and optimize combination therapies.
The parameter values explored are limited and the focus is on optimizing combinations of LBP-based descriptors that work well for several types of texture datasets.
Clearly, rapid and high-throughput means for optimizing combinations of two or three linkers in FRET-based biosensors could accelerate the development of improved tools for both basic biochemical and applied pharmaceutical research.
Figure 9 Optimized combination of N and k.
In the other aspect, the linear optimizing combination resampling (LOCR) algorithm is used to overcome the particle diversity deficiency.
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