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Indeed, it is essential that we know what mediating variables are relevant for particular outcomes in randomized clinical trials and that we design interventions to optimize change in the mediators of interest.
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Our approach would allow policy makers to evaluate and spatially optimize changes to the built environment that would yield the greatest health benefit per dollar.
Since the treated cells need to go through 2 rounds of cell division before changes in methylation sensitive genes occur (16), it is often necessary to test a range of concentrations to optimize changes in gene expression.
Meanwhile, to avoid smoothing out the details of the shape in variational modeling, we optimize the change in the deformation energy instead of the total energy of the deformed shape.
These criteria were applied to optimize State Change numbers for RCR.
For instance, following a systematic review, Flodgren and colleagues [ 97] concluded that 'Financial incentives may be effective in changing healthcare professional practice' [ 97], p. 2. Yet, research is required to determine the conditions that optimize such change.
To optimize morphological changes induced by the gate effect, the flexibility, density, and the amount of specific binding sites for templates of the MIP-grafted layer must be tightly controlled during radical polymerization.
In this study, to optimize the changed cyclone performance, one of the twin cyclones in the first-stage of the preheater tower, which had the most significant effect on particle separation from gas was simulated and validated by computational fluid dynamics.
In such cases, the comparisons may be biased in favor of treatment alternatives, to optimize the changes to eliminate the infection.
Greek symbols correspond to fossil-based minimum age constraints placed on the phylogeny in Figure 2. The r8s penalized likelihood method with the TN algorithm uses semiparametric rate-smoothing to optimize rate changes among branches.
Providing that systemic blood flow has been optimized based on indicators of global tissue perfusion, renal perfusion can typically be optimized by changes in vascular tone and re-distribution of systemic blood flow.
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