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Early phase clinical trials frequently combine targeted agents to optimize benefit.
In light of the modest benefits obtained with transplantation of rodent astrocytes isolated directly from the immature CNS [49] [53], however, our present and earlier studies [14], [57] suggest that it is necessary instead to transplant astrocytes generated from precursor cells in vitro in order to optimize benefit.
22 As such, an appropriate transfusion threshold in the elderly that would limit risk and optimize benefit would be advantageous.
The majority of GPs considered that, to optimize benefit for patients, such courses should be integrated in a comprehensive therapeutic plan.
Taken together, these findings provide experimental evidence in humans to support aggressive normalization of plasma glucose using insulin in patients with T1DM who experience repeated bouts of ischemia, in order to optimize benefit from insulin-induced protection and endogenous protection by ischemic preconditioning.
In addition, because of its psychoactive side effects, difficulty in dose titration to optimize benefit, minimize side effects like dizziness, dysphoria, depression, hallucinations, alteration in psychomotor function and paranoia, time to response and long-term effects when taken orally limits the use of this agent for all cancer patients with symptoms of cancer anorexia [ 41].
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In two experimental studies, I identify conditions in which consultant recommendations and, in turn, manager MCS choices intend to benefit management rather than optimize benefits for the firm.
Thus, our study suggests that a better adherence to antihypertensive agents is related to a risk reduction of ESRD and this adherence needs to be improved to optimize benefits.
Strategies for better educating patients about these issures merit attention, and research to identify effective approaches to educate patients and their parents to the potential that treatment side effects may arise which may undermine wellbeing so that early ameliorative action can be taken to optimize benefits and minimize harms.
Further, amphibian conservation efforts should account for potential Allee effects in order to optimize benefits and avoid underestimating critical population thresholds, particularly in species exhibiting rapid population declines.
Early vasopressin infusion may optimize benefits similar to early goal-directed therapy [ 87].
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