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All parameter optimization, template fitting, and model selection was conducted using the software package R version 2.12.1 (R Development Core Team 2008).
To make fair comparisons between the f-SA and p-SA plans, a volumetric dose optimization template (Table 1 ) was created to ensure that at least 95% of the PTV received the prescription dose in 44 fractions while keeping the dose to OARs below the planning limits.
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Five topological optimization templates were proposed to improve the quality of degenerated elements.
This library also gives the possibility to expand optimization templates.
Heterocycle optimization and template modification lead to the identification of compound 24 which demonstrated increased atrial effective refractory period in the rabbit pharmacodynamic model with mild effects on blood pressure and heart rate.
After optimization and template based alignment of these compounds, descriptors representing steric, electrostatic and hydrophobic energies at all lattice points of the grid around the molecules were computed.
In order to obtain the neutral and membrane-permeable prodrugs, great attention has been paid to the optimization of this template, and several highly potent virus inhibitors have been successfully produced.
However, despite continued improvements in screening techniques (Kim et al. 2014; Arribere et al. 2014; Ward 2015) and template optimization (Paix et al. 2014), we and others have had difficulties achieving consistent HR-mediated modification events (Farboud and Meyer (2015), and our unpublished results).
The multi-objective optimization-based placement template generator inputs a Pareto set of sizing solutions and outputs a set of optimal sizing-independent non-slicing B*-tree floorplan representations, i.e., placement templates.
With the rational design of the DNA template and optimization of the synthetic buffer, as well as the NaBH4-to-Ag+ ratio, the growth time and purity of the obtained aptamer-functionalized Ag NCs were improved.
The obtained results would help to better design a remediation technology to be applied to the sites contaminated with mixed wastes, and the statistical methodologies used in this study appear to be very efficient and could serve as a template for optimization.
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