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Using structure-based optimization procedures on in silico hits, dibenzosuberyl- and benzoate substituted tropines were designed as ligands for acetylcholine-binding protein (AChBP).
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The present paper demonstrates this optimization procedure on a new optical precision sputter coater "Enhanced Optical Sputtering System (EOSS)" at Fraunhofer IST.
We applied our optimization procedure on a number of benchmark problems and compared its performance with some well-known methods including genetic algorithms (GA), particle swarm optimization (PSO), differential evolution (DE) and distributed dual averaging (DDA) algorithms.
Two more steps lead to the new best estimation of the posterior maximum at time t. Figure 11 Example execution of the proposed optimization procedure on a 2D synthetic example, showing three iterations.
In order to avoid onerous analysis of the frame models, an equivalent procedure is introduced for performing the optimization procedure on the modified reduced shear-building model of the frames, which is shown to be accurate enough for design purposes.
The optimization procedure on a transport aircraft wing torsion box has showed 29% weight reduction compared to an initial quasi-isotropic laminated structure and 54% with respect to the metallic structure.
It is shown that the proposed scheme is able to reduce up to 6.4% of the structural weight, when compared to a classical size optimization procedure on original structures.
In this section, we give a detailed account on optimization procedures for the generation of cold and dense radical beams using a Stark decelerator.
The coded OFDM signal is optimized through genetic optimization procedures based on radar image quality parameters.
With this experimental protocol, we could not compare our results with the ones that would have been obtained by using other optimization procedures based on the assessment of mechanical properties (such as Cdyn).
In this article, we propose efficient robust topology optimization procedures based on reanalysis techniques.
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