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In the fourth section, we optimize the theoretical model in order to achieve an equal optimization period that maximizes the overall revenue of all groups through COA algorithm.
In this case, the configuration optimization period is one week.
For the deterministic optimization period, (rho_{s} = 1).
Heterogeneous population with the same optimization period of the developed model and optimization point are presented in this study.
The objective is to minimize the total VC of the three subsystems for one optimization period with T time intervals as in (1).
Considering the limited computation resources, an implementation mode based on off-line parameter optimization, period parameters updating and on-line load forecasting is proposed.
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Long time-horizons are explored, aiming to avoid typical peaks in drug prescriptions found at the beginning and at the end of the optimization periods.
Third, the novelty of the technology has required extended learning and optimization periods for both manufacturers and implementers, thereby slowing or decreasing its spread, especially in the early years.
If an acceptable response to treatment was not achieved, adjustments to higher doses were to be made at weekly intervals during the dose-optimization period.
A total of 215 patients were included in a 5-week dose-optimization period followed by 2 weeks on a stable dose.
There was a 5-week dose-optimization period, a 3-week dose-maintenance period, and a 9-day dose-taper period.
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