This was done through three main steps, that is, (1) the development of the "building blocks" of the test (i.e., speech stimuli and background noise); (2) the definition of the test sequence (i.e., the list of stimuli and the associated levels of background noise); and (3) the optimization of the test outcomes so that the agreement between the test outcomes and hearing impairment was the highest.
After optimization of methods, the outcome of which is described in the Experimental section, we established that infection of Sf9 cells with the tagged IP3R1 construct shown in Figure 1(A) allowed the expression of functional IP3R at a level considerably exceeding that of endogenous IP3R.
The development of new therapeutic resources for use in combination with physical rehabilitation methods is of fundamental importance to the optimization of the functional outcome [ 13].
Our results call for a controlled evaluation of different surgical approaches to investigate the optimization of outcome in the context of the required compromises between seizure control and memory function.
Measurements of energy-power at different depths in the tissue have been carried out in order to fully understand the effects of tissue-laser interaction for the optimization of clinical outcomes.
The clearest notions associated with rationality are coherence and consistency in the sphere of belief, and optimization of outcomes in the sphere of action.
The main challenge in the design of vibration energy harvesters is the optimization of energy outcome relative to the applied excitation.
Like many other therapeutic areas in critical care, an approach to fluid administration that employs therapeutic minimization may be preferred for the avoidance of complications and optimization of patient outcomes.
The goals of an antimicrobial stewardship program include optimization of clinical outcomes while minimizing unintended consequences of antimicrobial use such as toxicity, and the emergence of resistance.
These results suggest fundamental differences between stem cell-based (MSC) and primary cell-based (hCH) tissue engineering, as well as the importance of suitable scaffold features, in the optimization of cartilage-related outcomes in vitro.
