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An optimization of the iterative clustering method implemented in that program was therefore mandatory.
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The mode of binding and specific interactions between the protein and the inhibitor provide insight into the high potency of this class of macrocylic compounds and may aid in further optimization as part of the iterative rational drug design process.
Since the dimension of the search space depends on the number of linearly independent correction vectors, a sufficient number of correction vectors ensure effective optimization, and the iterative updating of all the one-electron wave functions leads to smooth convergence to the ground states.
The iterative optimization of the
As explained at the end of Section 3, the iterative optimization of the PS standardization, i.e. Step 9, is important.
The objective of the optimization is an auxiliary channel based lower bound on the achievable rate similar to the one introduced in Section 3. The proposed sequence optimization approach [34] follows the principle of the iterative Markov source optimization suggested in [22].
We perform the optimization of the code through an iterative linear programming algorithm in contrast to the code design in [3], which is achieved through differential evolution, a complex non-linear constrained optimization algorithm.
The available complex simulation model is used as surrogate plant to generate control relevant input and output trajectories and both an optimization of the input and an iterative nonlinear identification procedure are used.
'Hill climbing' is a mathematical optimization technique for the iterative searching of local or global extreme value of functions of one or more variables.
The simple electrostatic model used in the optimization of rotamers by iterative techniques (ORBIT) force-field, which is similar to the electrostatic models used in other protein design force-fields, is unable to predict the experimentally determined stabilities of the designed variants.
The detailed procedure of the iterative optimization algorithm is listed in Table 2.
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