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Our observations, as well as the observations of others, suggest that optimization of ones protocol to a surface chemistry is an essential first step to generating reliable global gene expression measurements using in-house spotted microarrays.
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The proposed approach in [12] is justified by the simple reason that, in almost all cases, the segmentation process, based on the optimization of one criterion only, does not work very well for many images.
Previous publications reported on comparison and optimization of one matrix application method for a variety of matrices, comparison between dry coating and spray matrix application methods, or comparison between two different spray methods.
This model will improve the optimization of one or several decision methods based on experts' knowledge of the company.
Topology optimization of one Conor stent strut was based on the commercial finite element analysis code OptiStruct, with the aim of increasing the strut stiffness while retaining its drug holding capacity.
The nominal optimization of one single realization was also adopted for the comparison.
Optimization of one of those ten resulted in the discovery of FIN56, a specific inducer of ferroptosis.
Optimization of one automatic rendezvous controller with 18 design parameters is illustrated.
Finally, achieving reliability and bias jointly is a daunting challenge as the optimization of one score is done at the cost of the other.
The problem can be rigorously addressed through the optimization of one or more objective functions that represent the managerial goals associated to the network.
I. Celanovic, F. O'Sullivan, M. Ilak, J. Kassakian, and D. Perreault, "Design and Optimization of One-Dimensional Photonic Crystals for Thermophotovoltaic Applications," Optics Letters, Vol. 29, No. 8, April 15 , 2004 pp. 863-865.
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