Sentence examples for optimization of compounds from inspiring English sources

There are many obstacles along the journey from initial hit-finding activities, through optimization of compounds and eventually to delivery of robust candidate drugs (CDs) for clinical evaluation.

The results also offer a theoretical background enabling the design and optimization of compounds endowed with allosteric enhancer, competitive, agonist, antagonist, and inverse agonist properties.

He also emphasized that MALDI-MSI approaches will play an increasingly important role in both drug development in the optimization of compounds and in clinical efficacy testing.

12 Raltegravir MK-05188), is a direct result of the optimization of compounds related to the naphthyridine carboxamide family.

Also, increased lipophilicity often results from optimization of compounds that extend into lipophilic pockets near the binding site.

Optimization of compound 30 led to high-affinity inhibitors.

The optimization of compound properties may require some type of multiparameter optimization scheme in library design.

Additionally, optimization of compound C12 may result in discovering the fourth-generation EGFR-TKIs.

Further optimization of compound 10 led us to compound 14, which demonstrated an improved pharmacokinetic profile and inhibition of IL-2 production in a mouse.

The selection of the ingredients and the optimization of compounding procedures has always been a challenging job for polymer scientists and engineers.

The obtained results, along with a 3D-QSAR study and molecular docking that were used for investigating the probable binding mode, could provide an important basis for further optimization of compound 6f as a novel anticancer agent.