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This model could be used to design best-fit mRNA sequences having a desired protein expression level, thereby facilitating protein over-production in biotechnology or the protein expression-level optimization necessary for the construction of robust networks in synthetic biology.
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The number of parameter optimizations necessary to achieve convergence under this criterion became even larger in other cases.
In contrast to previously published methods, our algorithm computes provably optimal solutions without computationally demanding parameter optimization usually necessary in heuristic approaches.
To design optimal reactors for such systems, a rigorous optimization is necessary.
Further optimization is necessary to obtain a high molecular weight, semicrystalline poly BTDA-DAB) upoly BTDA-DAB mouponng.
The results show that optimization is necessary for S′, H and θ to minimize ATC.
pH step elution protocols are derived from model calculations without further optimization experiments necessary.
Technology development and process optimization are necessary to minimize the overall production cost.
Due to the increasing complexity in products and in the resulting enterprise processes, new concepts for process optimization are necessary.
Given the limited variety of reversed phase plates, mobile phase composition optimization is necessary to obtain better separation of analytes with similar characteristics, which is often a time consuming step.
Hence, an optimization is necessary.
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