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Against such optimistic speculations we must set the obvious difficulties inherent in a deal open to very different interpretations by those who have set their hand to it.
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Although he indulges in some optimistic speculation about the promise of enhancing fetuses with "epigenetic smart drugs," Dr. Spector stresses that we are still mostly in the dark about how our genes work.
Already, advance ticket sales for next summer's Tests against Sri Lanka and Pakistan are exceeding even the most optimistic speculation.
Their experiments done, the Viking landers slowly died in the bitter cold of Mars, and centuries of optimistic speculation died with them.
Rather optimistic speculation in Italy has Trezeguet moving to Lyon in a part-exchange deal involving Karim Benzema, but in the likely event that such a deal does not transpire, Ranieri may well decide his team is now capable of proceeding without the striker.
Unfortunately, all of the optimistic speculation came crashing down.
Speculation was rife.
I am not optimistic that other offers will materialize, despite rampant speculation about who else may be in a position to bid.
Both the NEA and NEH had remained publicly optimistic and refrained from what the agencies termed "speculation" on federal appropriations for 2018. .
Early speculation that British Energy will command a price of up to £12bn appear increasingly optimistic with bids expected to be closer to half that.
Following months of speculation as to what the impacts would entail, the event itself proved equal to the most optimistic predictions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com