Its potentially adverse effects, incorrect identification of differentially expressed transcripts and overly-optimistic significance tests, can be fully avoided, however, by the sound application of recently established theory and models for data analysis.
Mr. Mundy said he was optimistic about the significance for gay immigrants of Mr. Holder's action.
Neglecting inter-subject variability in likelihood of recurrence results in an overly optimistic assessment of statistical significance.
While this optimistic perspective on the biological significance of network topologies generated considerable excitement in some quarters, it has not gone unchallenged.
For our analyses, we used the more optimistic binomial test and determined significance using an uncorrected p-value threshold of 0.01.
These problems include underpowered studies or overly optimistic reporting of effect sizes and significance levels due to multiple testing, subset analyses, and cutpoint optimisation (Altman et al, 1995).
This yields the most optimistic or most conservative estimate of real significance, and consequently is very susceptible to outlier p-values.
Over-optimistic models can result from multiplicity when significance testing is used on a large number of candidate variables, particularly with the small study sizes found in this sample (Altman, 2006).
Previous work demonstrated that the models were suitable for clinical use, and that overly optimistic or pessimistic estimates generated by PATHFx were of unequal clinical significance [ 14].
And while he said the team were optimistic that upgrades on their car had worked, he played down the significance of setting third fastest time on Friday.
At the risk of being over-optimistic, let us hope Ferdinand's persecutors saw it, and understood its significance.
