A Box Behnken design was used to optimise the extraction conditions for polysaccharide from Nostoc commune.
The central composite, non-factorial design was used to optimise the extraction conditions, using the Statistica, version 5 software (Statsoft).
Studies were carried out to assess the extraction yield of tomato waste carotenoids in different solvents and solvent mixtures and to optimise the extraction conditions for maximum recovery.
These data allowed us to define new basic parameters for the malaxer design and to optimise the extraction performance, thus ensuring the production of high-quality olive oil.
Multivariate analysis was used to optimise the extraction variables (ethanol:water:acetone solvent proportions, times, and acid concentrations) at different levels.
Response surface methodology (RS M based on a central composite design (CCD) was applied to optimise the extraction conditions for flavonoids from fructus sophorae with advantages in terms of resisting flavonoids during the whole process and maximising of extraction yield.
Response surface methodology (RS M was applied to optimise the extraction of curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) from turmeric using ethyl lactate (EL), ethanol and water under mild conditions (magnetic stirring at room temperature).
A simplex-centroid design comprising three solvents (water, ethanol and methanol) was used to optimise the extraction mixture for phenolics and antioxidant activities from defatted soy flour fermented with Monascus purpureus or Aspergillus oryzae.
An initial five-factor (ethanol concentration in the extraction solvent, liquid:solid ratio, time, power and temperature), five-level orthogonal experimental array was designed and three factors (ethanol concentration in the extraction solvent, liquid:solid ratio and time) plus their best levels were chosen to optimise the extraction using a central composite rotatable design (CCRD) experiment.
Mussatto et al. (2011) optimised the extraction of antioxidant phenolic compounds from SCG and found that extraction using 60% methanol in a solvent/solid ratio of 40 ml/g SCG, for 90 min, was the most appropriate condition to produce an extract with 16 mg GAE/g SCG of phenolic compounds having high antioxidant activity, i.e. Ferric reducing antioxidant power (FRAP) of 0.10 mM Fe(II)/g).
