In addition to ensuring appropriate compliance with minimum spacing requirements, occupied building studies to achieve compliance with the requirements of API 752 and API 753 could also be undertaken to optimise safety outcomes.
This optimises safety but complicates interpretation of drug levels associated directly with any single medication change.
To optimise safety and efficacy information, the sample size was set to 42 patients per arm.
Our challenges are to optimise the design of treatments in terms of combination and/or sequences and to optimise safety regarding the new adverse events that are occurring.
Low starting doses can optimise safety and minimise the risk of acute flares; doses should be gradually increased until target SUA levels are achieved (see recommendation 8).
In addition, the SEURAT-1 project COSMOS (COSMetics to Optimise Safety) (COSMOS 2011) has developed a database, COSMOSdb (COSMOS 2014), that includes a large number of toxicity studies with emphasis on substances used in cosmetics.
The Monitoring Medicines project (MM), with the full title "Optimising drug safety monitoring to enhance patient safety and achieve better health outcomes", was set up in 2009 with a consortium of 11 partners from Africa, Asia and Europe (Table 1).
The transport minister, Alexander Dobrindt, announced a new regular taskforce for optimising flight safety.
The transport minister, Alexander Dobrindt, announced the launch of a taskforce for optimising flight safety.
