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The flow and transport models were calibrated using a manual iterative parameter approach and the parameter optimising programme PEST (Doherty 2004).
Thanks to the development of an optimising programme, based on the genetic algorithms theory, it was possible to find an optimal solution.
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Because the choice and dosage of ChEI for each individual patient was left entirely to the physician's decision, a common dose-optimising programme for this study was not applied.
Therefore, it is crucial to focus on partner testing and involvement in the PMTCT programme to optimise programme effectiveness.
It is imperative that donors and the scientific research community respond to these gaps in order to update the guidelines and optimise programme implementation.
This understanding will enable lifestyle intervention developers to optimise programme components that will best suit the target groups' needs and are therefore more likely to be relevant to them (Krumeich et al., 2001).
The high cost of maintaining parallel disease-specific programmes, and the potential benefits of integrated services with unified finance, management and M&E processes provide compelling reasons to adopt organisational arrangements that optimise programme integration, particularly in weak health system contexts [ 15].
We have described activities aimed at optimising the programme in the dimensions supporting and documenting.
Such improvements will ensure progress towards optimising the programme and improving access to healthcare in the public service.
Firstly, documentation will facilitate learning of the organisation by allowing the cyclic system of optimising the programme in action to function properly.
We need to help governments better collect and open their own administrative data to improve transparency and optimise their programmes.
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