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Since destabilising (negative) mutations prevail in the available experimental data (74% in our data set), optimising on MCC allowed us to achieve a more balanced performance in terms of correctly predicted both stabilising and destabilising mutations.
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Optimised for on-track performance, the Z/28 uses the hand-assembled, naturally aspirated 7-litre LS7 V8 from the Corvette Z06, which produces more than 500hp.
While input parameters for simple models that rely on bulk measures of the lahar (e.g. internal and basal friction, solid concentration) can be calibrated to previous lahar flows, in practice, the complexity of lahar events mean the calibration can only be optimised on one characteristic of the lahar to the detriment of others.
Hence, a combination of both methods ("REFT") was used to optimise on the one hand, the standardisation of the outlines according to orientation and starting point, and on the other hand, a minimal number of variables [26].
To this end, a fast all-in-one protocol was developed and optimised on this platform to isolate mRNA from 1 mL of whole blood, followed by a cartridge-compatible one-step RNA specific RT-PCR protocol for the four mRNA markers (CD177, LCN2, MMP9 and OLFM4) and the housekeeping gene (B2M).
The method was optimised on pure fungal DNA and on plasmid standard dilutions.
The parameters for the structure design have been optimised on SolidWorks 2012 platform.
In experiments, a rectangular building's design was optimised on a flat and urban dataset.
To optimise on classic flooding, they typically make use of contextual information such as node location or neighbourhood, or rely only on observations of ongoing packet exchanges.
The thresholds optimised on the internal test set were used for predicting the activity classes of the molecules in the external validation set.
Size and composition of the molecular vector are optimised on the basis of the selected synthesis criteria without limitations on the type of calculations required.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com