Maximising uptake of pesticides is important to optimise efficacy and cost-effectiveness of any chemical control strategy.
In the current context of a discrepancy between the demands of services and the resources available, such a synthesis could lead to modifications in the ways legislation and policies are used to optimise efficacy, quality and, ultimately, access to services.
In this review, we will discuss current findings to support the hypothesis that in most scenarios, combination with other therapeutic modalities will be required to optimise efficacy and current evidence for the molecular mechanisms that underpin potential combinations.
In addition, due to the presence of non-CD133-expressing cells in primary tumours, to optimise efficacy it may be necessary or desirable to kill adjacent tumour cells that are not expressing CD133.
In the current context of a discrepancy between the demands of services and the resources available, such an understanding could lead to modifications in the ways legislation and policies are used to optimise efficacy, quality and, ultimately, access to services.
Optimising the efficacy of a combination of IRI and FU could help to enhance the overall efficacy of chemotherapy in CRC as first- or second-line therapy.
Should such an agent reach clinical trials, measurement of serum levels of YKL40 may provide an opportunity to stratify patients, given the reliable detection of YKL40 in serum and thus optimising the efficacy of YKL40-targeted approaches.
New endocrine therapies with novel mechanisms of action provide opportunities not only for optimising the efficacy of breast cancer treatment, but may also allow a longer time in which endocrine therapies can be used before reliance upon cytotoxic chemotherapy is necessary.
Introduced in the 1960s, dihydropyridines have undergone several changes to optimise their efficacy and safety.
In cases where there are limited resources for the eradication of an epidemic, or where we seek to minimise possible adverse impacts of interventions, it is essential to optimise the efficacy of control measures.
