Further developments of our approach include the exploration of alternative strategies to optimise the identification of the treatment target population, and the description of a method to design those strategies.
Therapeutic approaches for the repair of bone could be optimised by the identification of a stem cell source that does not show age-related changes.
The administration of targeted anticancer therapies can be optimised by the identification of predictive biomarkers that segregate responders from non-responders, and the evaluation of pharmacodynamic biomarkers that provide functional proof-of-mechanism (Gutierrez et al, 2009).
Optimising the management of invasive plants requires the identification of the population size outcomes for alternative management strategies.
To optimise the efficacy of the CRAd ZD55, the identification of tumour-selective promoter elements that can differentiate between normal and cancer cells is of immense importance.
Strategies are necessary to optimise use of natural language processing in the identification of AMI in these electronic healthcare record (EHR) data.
This study validated and optimised ICD-10-CA-coded case definitions for the identification of sepsis and severe sepsis in administrative data.
The carcinogenic potentials of 40 National Toxicology Program chemicals previously predicted by Computer Optimised Molecular Parametric Analysis for Chemical Toxicity (COMPACT), based on the identification of potential substrates of cytochromes P4501A and 2E (CYP1andnd CYP2E), have been compared with new rodent carcinogenicity results.
We have developed, optimised and validated a H5 pseudoparticle-based (H5pp) serological assay for the identification of H5N1 neutralizing antibodies and this assay correlates well with the conventional micro-neutralization test [16].
The identification of patients' health needs is pivotal in optimising the quality of health care, increasing patient satisfaction and directing resource allocation.
