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These factors were further optimised using RSM.
The number of factors was optimised using the validation set.
The parameters were optimised using experimental design methodology.
The procedure was optimised using Design of Experiments (DoE).
These parameters have been optimised using Genetic Algorithms.
The mass spectrometric parameters were optimised using the Masshunter optimizer software (version B.03.01).
Temperature and time were optimised using the method of steepest ascent.
The extraction conditions were further optimised using response surface methodology (RS M.
Process conditions were optimised using response surface methodology with a Box-Behnken experimental design.
Few selected experimental parameters were optimised using Central Composite Design feature of Response Surface Methodology (RS M.
Therefore, some of these factors were optimised using a central composite designs.
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