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The resulting knowledge is automatically merged and organised into a single common SOHN for which we can apply the same prediction and SAR analysis tools, allowing the end user to access an optimised model for both predictive and knowledge discovery purposes (Figure 25).
Here we describe the use of PNAs incorporating a series of arginine residues in their backbones as polyarginine mimics either at the C2 or at the C5 positions potentially able to perform specific inhibition of miR-210 in the K562 and other cellular lines, with the aim of developing an optimised model for cellular uptake, biostability and anti-miR activity.
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This differentiation revealed several differences both in their dinucleotide frequency biases and in the optimised models for their underlying mutational and selection biases.
The obtained optimised model could be used for polyphenol extraction from star fruit pomace and microencapsulates can be incorporated in different food systems to enhance their antioxidant property.
The developed hull form optimization tool is applied to the hydrodynamic design optimization of a Series 60 model, and model tests are carried out on the original and an optimised model at WHUT (Wuhan University of Technology) for validation.
Proteins with significant VIP throughout the cross validation of the model were selected for the optimised model.
This procedure resulted in a table of occurrence frequencies for each interaction of the optimised model (Additional file 2).
The optimised model was then built with each of these 20 data sets, and pooled estimates of model coefficients and variances calculated using the rules devised by Little and Rubin 34 for comparison.
Thus optimised models can be used for structure-based drug design and virtual screening.
Different model quality assessment programs were employed for validating the refined and optimised models.
Instead they are optimised using a model for covariance which respects the physical attributes of the robot arm and its linkages.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com