Using an X-ray crystallography/structure-based design approach, the benzomorpholinone series was further optimised, increasing activity against T. brucei NMT by >1000-fold.
18 Cathelicidins vary in length, sequence, and structure, having extended, α-helical or β-hairpin folds; however, some are short linear molecules (for example, indolicidin, 13 amino acids), and these are ideal starting points for the design of synthetic peptides with optimised biological activity.
In addition, such proteins can be further optimised to increase activity, specificity and stability and they can be used as part of gene and cell therapeutic approaches [ 31, 33– 33].
These catalysts were optimised for oxidation activities by designing orthogonal experiments.
PET/computed tomography (CT) imaging of [18F]BF4 − produced by the optimised high-specific-activity methods described above was performed in 4 8-week-old female BALB/c mice (n = 3 per SA group).
It was envisaged that through modification of the diamine component, the orientation of the mechanistically important N-H bond could be optimised to maximise catalyst activity and selectivity.
In this study, the extraction conditions for the maximum recovery of polyphenols with high antioxidant activity were optimised by response surface methodology (RS M in Feronia limonia fruit.
In this paper, we address how the kit could be further optimised to increase specific activity and radiolabelling efficiency of His-tagged proteins, at suitable labelling rates with reduced wastage of protein and radioactivity.
Scheduling studies indicated that activity was optimised when ASA404 was administered shortly after chemotherapy (Siim et al, 2003).
As obligate biotrophs, AM fungi receive their entire carbon requirements from a 4 to 30% proportion of plant photoassimilates [ 41], and consequently, photosynthetic activity is optimised for symbiosis demand [ 42].
