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Furthermore, monitoring of replacement therapy to optimise the individual replacement dose or make dose adjustments is largely based on clinical signs and symptoms, rather than objective biological serum markers assessing the tissue activity of cortisol.
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Currently there are limited studies to support that current interventions optimise and maintain the individual's PA in the long term [ 15, 16].
The next step will be to optimise treatment for the individual patient, who is interested not only in the oncological outcome but also in functional results and subsequent quality of life.
However, as not all patients do respond to chemotherapy, there is a need for predictive and prognostic factors in order to optimise the treatment for individual patients.
Texture modified diets may be enriched to optimise the opportunity for individuals to meet their required energy intakes; however there is insufficient evidence supporting this strategy.
Within populations, individuals are rarely identical; rather, there often exists a pronounced degree of variability, independent of age or body size, which natural selection can act upon to optimise the fitness of individuals (Morozov et al., 2013).
This will not only serve to optimise the care of individuals with DSD, but it will also ensure that both short- and long-term outcome data are collected and translated into better future management strategies.
This problem might be addressed by optimising the protocol for the individual proteins, or by performing tandem-affinity purifications on isolated tissues or cells in which the proteins of interest are most highly expressed.
Currently there are no interventions for adolescents with CP in this critical life phase that optimise and maintain the individuals' physical activity in the long term.
In [13], the authors propose a low-complexity algorithm with fairness consideration to optimise the sum rate under individual rate and power constraints.
The current management of mRCC involves an evolving algorithm with a goal to optimise the outcome for each individual patient with as many lines of TT as the patient may benefit from.
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