Positive selection is guided by immediate selective advantage, whereas purifying selection may optimise the function of already existing adaptations (e.g., reduce energy costs, increase reliability and adaptability).
Classification algorithms, in particular, optimise the function specifically to the region of selection; this may explain the differences observed at higher or lower percentiles.
Summarising, we look for α, β, and x that optimise the function (3) Having obtained the hidden TFA of DosR, the derived TFA can be used to identify unknown target genes regulated by DosR.
Real time control (RTC) is increasingly seen as a viable method to optimise the functioning of wastewater systems.
'The missions are protecting the forest area, rehabilitating forest, encouraging the conservation of resources, optimising the function of forest utilisation, encouraging people's participation in forestry development,' Sastrawan said.
However, how to modulate rationally and optimise the metabolic function of these naturally engineered acidic ecosystems remains unclear.
Using the Lagrange Multiplier method, we need to optimise the objective function by solving = 0, where is an unknown parameter (or alternatively = 0).
Instead of fitting all the data, classification algorithms optimise the approximating function to separate the best and worst individuals.
In fact, we could have chosen a SVM solution where the goal was to optimise the loss function AUC (4) directly, see e.g. Joachims [ 23, 24].
If there are indications of pulmonary disease, patients will be referred to a pulmonologist to optimise the pulmonary function prior to the start of the programme.
Thus, the use of inotropic agents such as dobutamine [ 135], levosimendan [ 136], milrinone [ 137], and even intra-aortic balloon pump counterpulsation [ 138] has been described and can be considered to optimise the cardiac function in order to improve CBF.
