Sentence examples for optimise the activity from inspiring English sources

The challenges involved in using rational (3D QSAR-based) drug design to optimise the activity profile of analogues of 2MEO to provide additional members of this new class of anti-tumour/anti-inflammatory drug are also outlined.

15 Alcohol is frequently combined with CHG or iodophors to optimise the activity of the surgical skin antisepsis.

Nevertheless, to date the need for dosimetry to individually optimise the therapeutic activity to be administered has been far from self-evident.

Frequent dosing is required to optimise the antitumour activity of UCN-01 (Sausville et al, 1998), and 72 h of drug exposure is required to achieve growth inhibition.

This paper describes the modification of key structural elements of U50488 to investigate structure activity relationships (SAR) and to optimise the antiproliferative activity and pharmacokinetic properties of this compound.

Corals have evolved to optimise the photosynthetic activities of the resident Symbiodinium through changes to their morphologies [6], [7], [8] or through changes in tissue composition [9] or population density of Symbiodinium [10], [11].

The aim of this study was to identify a method for optimising the administered activity and acquisition time for fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) imaging for individual patients to ensure that images of consistent quality are produced for patients with varying body sizes and compositions, while limiting radiation doses to patients and staff.

The purpose of this study is to identify a method for optimising the administered activity and acquisition time for 18F-FDG PET imaging, yielding images of consistent quality for patients with varying body sizes and compositions, while limiting radiation doses to patients and staff.

Knowing how specificity is controlled, would allow to optimise this activity in an efficient way by means of enzyme engineering.

In an attempt to further optimise the anti-tumor activity in this young patient, the sunitinib dose was subsequently further up-titrated to 62.5 mg once daily (4/2 schedule) for the eighth treatment cycle, during which the patient experienced no toxicity, an improvement in PS from 1 to 0 and was able to return back to work.

The positive effect on activity performance in the reablement group may therefore be caused by factors such as increased confidence in performing activities, and by optimising performance through adaptations of the activity and/or the environment.