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In addition to ensuring appropriate compliance with minimum spacing requirements, occupied building studies to achieve compliance with the requirements of API 752 and API 753 could also be undertaken to optimise safety outcomes.
To optimise safety and efficacy information, the sample size was set to 42 patients per arm.
Our challenges are to optimise the design of treatments in terms of combination and/or sequences and to optimise safety regarding the new adverse events that are occurring.
Low starting doses can optimise safety and minimise the risk of acute flares; doses should be gradually increased until target SUA levels are achieved (see recommendation 8).
In addition, the SEURAT-1 project COSMOS (COSMetics to Optimise Safety) (COSMOS 2011) has developed a database, COSMOSdb (COSMOS 2014), that includes a large number of toxicity studies with emphasis on substances used in cosmetics.
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This optimises safety but complicates interpretation of drug levels associated directly with any single medication change.
This has the effect of transforming the overall systems process (relationships P1 - P4) from a partial and fragmented historical construction into a systematic adaptive-control process for optimising safety and quality of care.
For example, with support from the Office of the National Coordinator for Health Information Technology, we previously used a rigorous, iterative process to develop a set of nine self-assessment tools to optimise the safety and safe use of EHRs using our eight-dimension sociotechnical model.
A statement said: "Enabling PCCs to govern fire and rescue services will neither deliver economic, efficient or effective emergency services nor optimise public safety.
In order to optimise the safety of underground rock engineering construction and the long-term security of the resultant facilities, it is necessary to have a knowledge of the likely hazards.
How this is done, or the methods used, needs to optimise patient safety.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com