Further developments of our approach include the exploration of alternative strategies to optimise the identification of the treatment target population, and the description of a method to design those strategies.
We also report an algorithm that optimises the identification of patients with an increased case-capture rate for sepsis (although a slight increase in the number of false positives): this algorithm may be optimal for surveillance studies.
Therapeutic approaches for the repair of bone could be optimised by the identification of a stem cell source that does not show age-related changes.
The administration of targeted anticancer therapies can be optimised by the identification of predictive biomarkers that segregate responders from non-responders, and the evaluation of pharmacodynamic biomarkers that provide functional proof-of-mechanism (Gutierrez et al, 2009).
Cut-points in the MUAC distribution which optimised the ROC-AUC for identification of overfatness and obesity were determined for boys and girls aged 5 9 and 10 14 years, and had high sensitivity and specificity.
If the health service is to optimise the use of allocated resources, identification of the needs of individuals and of the local population, whether through a surrogate such as quality of life or formal needs assessment, is an essential first step.
To optimise the efficacy of the CRAd ZD55, the identification of tumour-selective promoter elements that can differentiate between normal and cancer cells is of immense importance.
