In the current context of a discrepancy between the demands of services and the resources available, such a synthesis could lead to modifications in the ways legislation and policies are used to optimise efficacy, quality and, ultimately, access to services.
In the current context of a discrepancy between the demands of services and the resources available, such an understanding could lead to modifications in the ways legislation and policies are used to optimise efficacy, quality and, ultimately, access to services.
In addition, due to the presence of non-CD133-expressing cells in primary tumours, to optimise efficacy it may be necessary or desirable to kill adjacent tumour cells that are not expressing CD133.
Introduced in the 1960s, dihydropyridines have undergone several changes to optimise their efficacy and safety.
Individualising doses according to UGT1A1 genotype has been proposed to optimise treatment efficacy and tolerance.
This enhanced understanding will orient decision-makers regarding avenues of intervention to optimise the efficacy and effectiveness of healthcare services.
3 Moreover, 'personalised medicine' has the potential to optimise treatment efficacy and minimise the toxicity of therapeutic agents.
However, to optimise the efficacy and safety of tumour vaccines, immunotherapy timing, regimen, dosage and administration protocols are still required for further research.
However, careful attention should be paid to defining the women to target, the device to use and to each logistical detail to optimise participation, efficacy and cost-effectiveness.
