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We define 'systemic solutions' as "…low-input technologies using natural processes to optimise benefits across the spectrum of ecosystem services and their beneficiaries".
These approaches may not be the best ways to optimise benefits.
As new agents enter clinical practice, a comprehensive research strategy is essential to optimise benefits whilst minimising harm.
In the absence of conclusive evidence on effects of integration, it is advised that countries adopt organisational arrangements that optimise benefits for both programmes and systems in their context-specific settings [ 9].
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In conclusion we identified three characteristics that facilitate a deliberate treatment choice, to optimise benefit of treatment in patients with non-specific neck pain: age, pain intensity, and (no) accompanying low back pain.
Markers of target engagement, blood pressure and sVEGFR2, and end points of safety and efficacy were examined to investigate the range of plasma pazopanib concentrations that could optimise benefit to patients with RCC.
Provided that there is sufficient knowledge about the health effects of various HRT formulations and modes of delivery, women and their physicians could potentially individualise treatment with HRT to minimise the health risks and optimise benefit.
The pop up model is one example of a model of care that has been recommended by policy without evidence for its effectiveness as a whole but rather an assumption that effective elements can be combined to optimise benefit [ 110].
They contribute to sustainable development by averting unintended negative impacts and optimising benefits to all ecosystem service beneficiaries, increasing net economic value.
At a national scale, regional differences should be taken into account when implementing policy objectives to optimise biodiversity benefits from set-aside.
However, when observed in vivo, and thus with external inputs acting upon it, a critical brain may no longer exhibit avalanches approximated by power laws but would instead optimise functional benefits such as the dynamic range and information transmission [17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com