A self-titrating regimen was used to optimise drug administration.
Therapeutic Drug Monitoring (TDM) is an evolving tool used to optimise the administration of antimicrobial agents; which are well documented to have toxic side effects [[1]].
The monitoring of ASNase activity/antibody and increasing the dose of PEG-ASNase in those who have inadequate activity/silent antibodies could optimise drug administration and lead to a better outcome.
PPV can be useful in determining the haemodynamic consequences of haemofiltration (that is, excessive fluid removal) or of positive end-expiratory pressure before a recruitment manoeuvre or to optimise fluid administration in acute respiratory distress syndrome, in which carefully monitored fluid management can affect lung function and duration of mechanical ventilation [ 23].
This process optimised the administration of PCC in emergent situations and reduced anticoagulation reversal delays in our ED.
Optimising intraoperative fluid administration may result in improved outcomes.
Such an environment raises an unprecedented demand for the dynamic, lightweight management of the multitude of mobile devices, to ease the complexity of their administration and optimise the overall system performance [1, 2].
The aim of this study was to compare the behaviour of three PPIs (omeprazole, lanzoprazole and esomeprazole) during the transit of the granules through the tube and to optimise their modes of administration.
A snack with approximately 5 g of fat is administered prior to both AL and primaquine administration to optimise absorption of AL and minimise gastrointestinal side effects with primaquine.
Our study stresses the importance in defining the best drug sequencing for combined administration to optimise a novel therapeutic approach (Xu et al, 2003; Azzariti et al, 2006a, 2006b).
This review discusses the pharmacological attempts at treatment optimisation, which include reducing interindividual pharmacokinetic and pharmacodynamic variability, optimising schedule, route of administration, reversing drug resistance and the development of structurally related second-generation taxanes.
