Sentence examples for optimisation programme from inspiring English sources

Further derivatisation produced compounds with IC50's <10 nmol for inhibiting the VLA-4 mediated binding of fibronectin to RAMOS cells, providing an ideal starting point for a lead optimisation Programme.

Both hit series were low molecular weight compounds with lead-like properties suitable for a medicinal chemistry optimisation programme.

Nintedanib is an indolinone derivative that was derived from a chemical lead optimisation programme designed for receptor tyrosine kinase inhibitors (Patent application WO2001027081, example 473).

The large number of lead optimisation programmes run at GSK over many years has resulted in many thousands of data points.

The Drug Discovery Unit (DDU) in Dundee has recently carried out screens and chemical optimisation programmes against several parasite protein kinases.

Three different libraries were assembled: a virtual screening set representing valuable starting points for lead optimisation programmes, a HTS library intended to be a diverse subset of these compounds, and a kinase library containing compounds that are likely to inhibit kinases.

Optimisation of vaccination programme design can be greatly facilitated through insights gained from the mathematical modelling of measles transmission dynamics [ 1].

This suggests the need for optimisation of the PFGE programme.

This book covers the patient journey through such a programme, commencing with optimisation of the patient's condition, patient education and conditioning of their expectations.

These findings, showing the metabolic hotspots in NU7026 provide a basis for further optimisation in this drug discovery programme.

Their retrospective drug use study found that the introduction of a multi-disciplinary dementia management programme including the optimisation of pharmacological treatment had led to reductions in prescription of psychotropic medications and increases in anti-depressant and anti-dementia medications.