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A process evaluation led to optimisation of intervention delivery.
Applied to humans this realisation adds another layer of complexity to the design optimisation of intervention trials using combinations of agents.
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The low levels of reporting of CKD raises issues around the optimisation of interventions and trial designs in this population [ 35].
Our list could also be used by healthcare managers, administrators and decisionmakers and policymakers to guide resource allocation decisions and inform local implementation and optimisation of interventions.
The results will inform future research and could be used by healthcare managers, administrators and policymakers to guide resource allocation decisions and inform local implementation and optimisation of interventions to reduce unscheduled hospital admissions.
Although rehabilitation following a TIA/minor stroke is widely recommended, there is a paucity of research that offers an evidence base on which the development or optimisation of interventions can be based, particularly for home-based approaches and non-pharmacological interventions in the acute period following the initial TIA/'minor' stroke.
The entire feasibility study, together with our previous work relating to the original NLNY intervention 8 and the related qualitative studies, including the interview study reported here, 9 will inform plans for optimisation of the intervention and options for definitive evaluation of the NLNY intervention for effectiveness and cost-effectiveness.
The results of the feasibility study may be used for optimisation of the intervention and may serve as a basis for implementation of the intervention in a randomised controlled trial.
All aspects of this protocol have been evaluated in a pilot randomised controlled trial, with subsequent optimisation of the intervention.
The findings of this pilot study enabled informed choice of outcome measures and optimisation of the intervention to be tested in the DQIP trial.
We planned this investigation, along with other outcomes of the feasibility study, to subsequently inform the optimisation of the intervention via discussion with the commissioners.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com