Dimensionless numbers for spray fluxes are useful to identify operating regimes and to steer optimisation efforts.
Optimisation efforts resulted in more than 20-fold improvement of activity, while the excellent enantioselectivity of the enzymes was maintained.
A key question is, what knowledge can be extracted from such large data sets that can help in future optimisation efforts.
Although the potency of our lead AF2 inhibitor, VPC-16230, is less than that of tamoxifen, one must note that this is an early-stage compound and that its activity can be enhanced by further lead optimisation efforts.
Plus, if your story gets published online, there's a chance you'll be adding to your own search engine optimisation (SEO) efforts as well.
A possible way to decrease the uncertainty, while also optimising measurement effort, could be the calculation of required number of Rs measurements (Nopt) together with the optimisation of their spatial arrangement.
We propose potential solutions for these problems, including improvements in protocols and documentation, consideration of evidence from studies in progress, standardisation of research efforts, optimisation and training of an experienced and non-conflicted scientific workforce, and reconsideration of scientific reward systems.
Guidelines for case selection, for the case elements/attributes that are highest priority for peer review, and for acceptable timing of peer-review activities would assist centres to improve consistency of practice, prioritisation and optimisation of their efforts.
Despite the effort of optimisation of the coating process, degradation of the feedstock materials such as decarburisation of WC and amorphization of the metallic phase still occurs.
It is of utmost importance to develop methods to assess the contributions of different stages in the chain of medical interventions to be able to define the relevant points of optimisation, which means putting effort into those parts of a medical application scheme where there is the highest benefit.
