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Clinical and translational medicine should optimally link all circles and processes, e.g. discovery science, early translation steps, clinical trials, clinical practice guidelines, performance measures, and outcomes together.
Secondly, the study aims to determine to what extent the triage instruments used in the program detect increased risk for functional loss and to determine how criteria for triage should be adjusted to optimally link the offered interventions to the needs of the individual elderly at risk.
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Several options should be tested: direct measurements via jaw splint or EMA [37], additional estimators linking tongue and facial movements [38], or more complex statistical models optimally linking residual appearance of the inner mouth to phonetic content.
To resolve congestion at each iteration, they first try to assign a new channel to then bottleneck then optimally allocate link rate among a group of contending flows that share this link by solving a linear programming problem.
Both algorithms identify instantaneous bottlenecks at each additional assignment iteration using routing and network topology information and try to resolve congestion by (i) assigning a new channel, (ii) channel switching (FOCA only), and (iii) optimally allocating link rate to contending flows by solving an LP problem.
Location analysis and network design are two major research areas in supply chain optimization; location problems deal with the decisions of where to optimally locate facilities, whereas network design involves activating optimal links (Contreras and Fernández 2012).
An optimal Ag concentration, reflecting the zone of equivalence, was thought to optimally cross-link all IgE-bound receptors, thus causing strong activation of Ag-triggered signaling pathways and maximal induction of effector functions.
As a result, it is extremely difficult to schedule links optimally.
The most significant limitation may be that our statistical models are less than optimally sensitive to linking the degree of disorder in the patient's circadian system and advanced lung cancer symptoms [ 51].
Preimplantation genetic haplotyping is a clinical method of PGD, which involves whole-genome amplification (WGA) of the biopsied material and analysis of multiple microsatellite markers linked or optimally flanking the mutation site, in order to provide a more practical, yet accurate (due to a low risk of recombination), indirect approach to mutation analysis.
Then the link rate is optimally allocated among contending flows that share this link by solving a linear programming problem.
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