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On the other hand, computationally designed ArmRPs, where side chains have been chosen with the intention to optimally fit into a geometrically optimized backbone, turned out to be more divergent in reality, and thus not suitable for continuous peptide binding.
These heuristics do not attempt to optimally fit parameters to a given environment; rather, they have simple structural features and "bet" that the environment will fit them.
Such a focus will allow more flexibility in the future and encourage practices to be "customized" to optimally fit specific ecological, economic, and social settings without the confining restrictions of labels.
The high affinity of this inhibitor can be attributed to its bulky cyclic moiety spanning P2-P3′ and other residues that appear to optimally fit the binding sub-sites of the enzyme.
Aim of this study was to investigate the effect of the preparation parameters on the characteristics of lipospheres that would optimally fit to a lab-on-a-chip platform.
We apply a calibration method to adjust design variables to optimally fit truncated mooring system to full-depth mooring system, in order to minimize the differences in motion and tension responses from the two systems.
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Recently a new functional constitutive relation was derived by Saimoto and Van Houtte based on Taylor slip analysis that is optimally fitted to replicate the measured data.
On average, the difference between predictive performance of internally and externally validated SF-models is not large with optimally fitted models (Table 2).
A three-pool (active, slow, and passive) C-cycling model was optimally fitted with 376 published laboratory incubation data from soils acquired from 73 sites with mean annual temperature ranging from − 15 to 26 °C.
The blue lines are data measured in the experiment and the orange lines are theoretical predictions based on the SLH model for the CCD with optimally fitted parameter values.
For example, problem Histamine H _2) receptor (HRH2) is a worst generalized model constructed by unscaled importance based feature selection, but was optimally fitted by the scaled importance based set of features.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com