The variability is also apparent in the few experiments in which the efficacies of different preparations have been compared quantitatively in animal models.24 Use of biomarkers such as expression of the inflammation-modulating protein TSG-6 may help select optimally effective preparations for some disease targets,24 but the development of biomarkers for MSCs is still in its infancy.
A leading hypothesis for why MetSyn is not optimally effective in detecting risk for CVD and T2D in African Americans is that hypertriglyceridemia, one of the three most common MetSyn variables in whites, is rarely present in African Americans (3, 5, 13– 13).
To be optimally effective, social cognitive wellness programs for persons with a chronic disease may have to be differentiated according to type of disease or degree of disability.
A more fine grained examination of which course components contribute the most to the effectiveness (or lack thereof) of a blended learning approach would both advance our understanding of how and why blended approaches impact student learning but would also provide more detailed guidance for implementing optimally effective blended learning courses.
In a remarkable reversal of therapeutic paradigms, the cautious approach employed until the late 20th century, known as the 'therapeutic pyramid' [ 26], has been reversed to call for an early, optimally effective initial (DMARD) treatment.
Nevertheless, most men would require more time for tadalafil to be optimally effective; in particular, patients with severe ED or older patients should be encouraged to optimize the period of sexual stimulation.
With resident and educator time at a premium, the identification of an optimally effective and efficient training strategy has significant implications for how surgical skills training is incorporated into residency programs, which is critical in today's environment.
Most studies have found that switching therapy tends to be optimally effective in patients whose viral load is fully suppressed for at least 6 months rather than the 3 months in our study [ 45].
Evidence for the effectiveness of self-management interventions in chronic musculoskeletal pain is equivocal and it is not clear for which sub-groups of patients SM is optimally effective.
