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How can combination therapy be optimally administered?
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In order to provide a clear understanding of the proposed methods, systematic and effective design tools of SDRE control are illustrated on a single-inverted pendulum nonlinear benchmark problem and a practical application problem of optimally administering chemotherapy in cancer treatment.
However, data on how to optimally administer such a pre-phase induction chemotherapy are scarce.
The prostaglandin/prostamide should optimally be administered once daily in the evening to get the peak effect during the morning hours when IOP is physiologically at its highest.
Moxibustion may be ineffective, the studies may have been incorrectly designed or the treatment may not have been administered optimally in the existing studies.
Optimally, PFA should be administered on an interval basis to ensure the sustainability of patient flow efficiency that was achieved from the interventions.
Nevertheless, severe underlying diseases limit our ability to administer optimally chemotherapy.
Because biological systems are unable to perform optimally under the influence of two or more simultaneously administered drugs, multi-target therapeutics can prove effective as they may be less vulnerable to adaptive resistance from the human body [ 76].
To optimally measure the level of psychopathological symptoms, various questionnaires were administered.
A previous factor analysis of 93 measures related to autism also reported four individual measures administered in ALSPAC via parental questionnaires that 'combined optimally to predict autism'.
EQ-5D data collected within randomised controlled trials may not optimally capture the disutility associated with SLE flares [ 20] when administered at set time points which may not have coincided with a patient experiencing a flare.
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