Sentence examples for optimally activate from inspiring English sources
In addition, activated RAS proteins bind directly to an N-terminal RAS-binding domain (RBD) on p110α, acting synergistically with the input from tyrosine-phosphorylated proteins to optimally activate lipid kinase activity (Rodriguez-Viciana et al., 1994, 1996).
These findings suggest that the proline regulatory axis is providing the redox turnover to optimally activate the c-MYC activation of glycolysis.
This "third generation" DC-targeting vaccine was designed to both target antigen to DC and optimally activate dendritic cells by aggregating CD40 trimers on the DC membrane surface.
Mammary organoids were grown from single Lgr5+ mammary cells in Matrigel, the substratum of choice for intestinal organoids, and in a growth factor cocktail containing EGF, Wnt3a and R-spondin, designed to optimally activate the endogenous Wnt signaling program of stem cells.
The AMI consists of a single shank array (20 contacts) and uses a stimulation strategy originally designed for cochlear implants since it is already approved for human use and we do not yet know how to optimally activate the auditory midbrain.
The basis for decreased binding of TIEG1 to the −600 bp construct is also likely explained by the presence of inhibitory factors/repressive domains located in the distal regions of the Runx2 promoter that block TIEG1's ability to bind to and/or optimally activate this promoter fragment.
It has been reported that ATPase activity of wild type RIG-I is optimally activated by short RNA ligands (Kato et al., 2008; Kohlway et al., 2013), suggesting that these RNAs help 'prime' the protein for interactions with ATP.
A reusability experiment was also performed, and it showed that the β-gal immobilized onto the optimally activated CP beads maintained 56.62% of its initial activity during the thirteenth reusability cycle.
Such LTP could occur at those synapses to visual cortical neurons optimally activated by the exposed orientation.
A recent study suggests that extrasynaptic GABAARs were optimally activated by ambient GABA under physiological conditions and a further increase in extracellular GABA concentration would not significantly enhance the effect of tonic inhibition on neuronal excitability [29].
It is further expected that NMDA-receptor-mediated long-term potentiation (LTP) at synapses to visual cortical neurons optimally activated by the exposed orientation is involved in the over-representation of that orientation.
