Exact(44)
Optimal stimulus frequency for the A-optimality criterion has been derived by Liu et al. (2004) whereas we derive here the optimal stimulus frequency for the D-optimality criterion.
Many previous simulation and experimental results, including Wang's, have demonstrated that neural responses are sensitive to certain parameters of the stimulus, but finding the optimal stimulus has been very difficult due to the high dimensionality of neural stimulation parameter space.
In lateral inhibition the optimal stimulus is not spatially uniform across the receptive field; rather, it is a discrete spot of light (in the case of the eye) or contact (in the case of a body surface), with contrast between central and surrounding regions.
Based on these results, we make several recommendations regarding optimal stimulus protocols, and conclude that an experimental design based on narrowband stimuli provides the best sensitivity to frequency-dependent responses to determine tonotopic maps.
Conclusion and significance: The optimal stimulus paradigm identified in this study (1 msec pulses delivered at 30 to 40 Hz and 2 to 8.5 mA) has been applied to implanted BVFP patients and improved outcome.
Recent progress in the experimental design for event-related fMRI experiments made it possible to find the optimal stimulus sequence for maximum contrast detection power using a genetic algorithm.
Similar(16)
A major goal of these characterization studies is to identify optimal stimuli for achieving desired cell functions, such as maintenance of stemness, proliferation, differentiation, and migration.
This pathway has been thought to be specific for threat, and although fearful face stimuli may serve as optimal stimuli for the subcortical face processing network19, it was shown in a blindsight patient that it could also convey other, positive emotions20.
It is suggested that electrospun scaffolds that couple conductivity and fibrous structure considerations may provide optimal stimuli to foster cell morphology and functions for myocardial regeneration or establishment of in vitro cardiomyocyte culture platform for drug screening.
The results from the behavioral experiment were used to select optimal stimuli for the fMRI experiment.
Cell selectivities and optimal stimuli were evaluated from PSTHs calculated on-line from the multi-unit recording.
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