This example suggests that the optimal starting point for lead optimization for β-sheet ligands is to identify short peptide sequences and the critical residues essential for binding (see section 4.2).
A rough-segmentation step is used to find the optimal starting point for the deformation and is based on thresholds and morphological operators.
We find that those strategies allow an economically optimal starting point for real-time balancing and create a marketplace for flexible capacity that is more open than alternative marketplaces.
In a comparison of the subscales and the summary measures in both groups upon study entry there were no significant differences, thus providing an optimal starting point for measuring the impact of PC on HRQoL.
Middle: Secure key rates for DSP using optimal starting points for those values of (r_{0}) that are too small to allow communication throughout the orbit (marked by pluses).
The overlay quality can be dramatically improved, in this situation, by slightly altering the methodology provided in this work to perform a post overlay optimization, using the near-optimal alignment-recycling overlay as a starting point for shape overlay optimization, providing substantial computational savings in the absence of such information.
It was noted that average concentration values derived from the literature search analysis may not be optimal but provided a sensible starting point for optimisation.
In conjunction with previous studies, these data provide a starting point for identifying optimal loading parameters that could be used during manual therapies, optimal time courses for their application, and the effects of manual therapies such as massage on the tissues' biological responses.
In a hierarchical optimization, in which the optimum obtained with a reduced model is used as a starting point for the optimization with the detailed model, an optimal design is found.
Success with, for example, Imatinib and Trastuzumab has suggested that identification and validation of the drug target is the starting point for the optimal route to the development of active drugs.
v_{i,G} = (v_{1,i,G},v_{2,i,G}, ldots,V_{D,i,G} )quad i = 1,2, ldots,{text{NP}}quad G = 0, ldots,G_{hbox{max} }. (20 An initial population should be created to establish a starting point for the optimal search.
