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This example suggests that the optimal starting point for lead optimization for β-sheet ligands is to identify short peptide sequences and the critical residues essential for binding (see section 4.2).
A rough-segmentation step is used to find the optimal starting point for the deformation and is based on thresholds and morphological operators.
We find that those strategies allow an economically optimal starting point for real-time balancing and create a marketplace for flexible capacity that is more open than alternative marketplaces.
By taking into account the unit prices of both processing time and utilized diluant, we provide a practical algebraic formula that allows decision makers to evaluate the optimal starting point of the constant-volume diafiltration step and to adapt it when considered prices change.
A peaceful mind is the optimal starting point for anything you would like to achieve, and it will give you the sense of support and reassurance you need to tackle the rest of your New Year's resolutions.
The study can provide prospectively collected data and a follow-up of more than 5 years, thereby being an optimal starting point for translational research in pancreatic cancer.
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Middle: Secure key rates for DSP using optimal starting points for those values of (r_{0}) that are too small to allow communication throughout the orbit (marked by pluses).
Based on the results of a sensitivity analysis, we find a specific relationship between the carpooling cost and the optimal design of the starting point of an HOV lane.
Second, it is also shown that the model globally converges to an exact optimal solution for any starting point from the feasible region.
Taking a Pareto-optimal contract as a starting point, the manufacturer wishes to design a real option contract to enhance profits.
The overlay quality can be dramatically improved, in this situation, by slightly altering the methodology provided in this work to perform a post overlay optimization, using the near-optimal alignment-recycling overlay as a starting point for shape overlay optimization, providing substantial computational savings in the absence of such information.
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