However, challenges remain in designing optimal proof-of-concept trials for the clinical development of compounds targeting the elimination of CSCs.
The refined model can aid optimal proof-of-concept phase II design and support an optimal dosing regimen.
Since p d,u (r tar,τ,T d,T u ) has the global extreme values for τ, the optimal τ can be derived (see Appendix A.3 Proof of Optimal τ ).
Applications of CNS PET imaging include establishing proof-of-mechanism and optimal dosing for novel therapeutic agents, allowing for accelerated decision-making in clinical trials.
Moreover, early intervention is optimal to achieve therapeutic benefit in this proof-of-principle experiment.
John Maynard Smith, for one, denies that they constitute proof of optimal adaptation per se.
This paper aims first at a simultaneous axiomatic presentation of the proof of optimal convergence rates for adaptive finite element methods and second at some refinements of particular questions like the avoidance of (discrete) lower bounds, inexact solvers, inhomogeneous boundary data, or the use of equivalent error estimators.
Using several proof-of-concept examples, we demonstrate that I-optimal designs offer both flexibility and small variances of prediction.
While useful as a proof-of-concept, this example is a sub-optimal demonstration of density estimation in two respects.
This was a proof-of-concept study that investigated the safety profile of DrotAA and determined the optimal dosage for future trials.
While the Kinect was good enough for the proof-of-concept, the team mentions in their paper that it's by no means optimal for their use.
