Sentence examples for optimal potency from inspiring English sources

Such exclusive scaffolds should be explored further for lead compound development with optimal potency and selectivity.

Novel zinc binding groups (ZBGs) represent a novel strategy to obtain optimal potency and selectivity for zinc metalloproteases inhibitors.

These preliminary results could provide a possible opportunity for the development of novel SHP2 inhibitors with optimal potency and improved pharmacological properties.

We propose that an understanding of this pathway could lead to drugs with optimal potency and selectivity in the treatment of type 2 diabetes mellitus.

A novel series of indole/indazole-aminopyrimidines was designed and synthesized with an aim to achieve optimal potency and selectivity for the c-Jun kinase family or JNKs.

Minimisation of this change is crucial for optimal potency and therefore not only conformational analysis but also understanding of the molecular drivers that control conformational preferences are both required if drug ligands are to be rationally and intentionally designed.

For cholangiocarcinoma, hepatocellular adenoma, CKE, and gingival SCC, the optimal potencies of PeCDF were 0.16, 0.34, 0.30, and 0.26, respectively.

For cholangiocarcinoma, hepatocellular adenoma, and gingival SCC, the optimal potencies of PCB-126 were 0.11, 0.09, and 0.09, respectively.

The stereoelectronic requirements for optimal antiviral potency were investigated.

One remaining challenge is how to achieve balance across all CNS preferred physicochemical properties together with optimal target potency.

The current need for the discovery and development of new lead compounds exhibiting optimal antitumor potency as well as anti-inflammatory activity.