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Given matrix [Ca2+], the initial guesses for the parameters need to be close to the optimal parameter estimates for the optimization algorithm to converge to the optimal parameter estimates.
Determining the optimal parameter setting is an optimization task in itself, which is extremely computationally expensive.
For each sample, we solve the optimization problem (20 ), obtaining one optimal parameter set.
After the systemic optimization we could then interpret the obtained optimal parameter values in the molecular realm.
The optimal parameter combinations differ per resolution.
The optimal parameter set is next applied on test data.
Select the optimal parameter set that minimizes the gap.
Figure 16 show that the optimal parameter a* = 0.4.
The four responses at optimal parameter setting have been reported.
This optimal parameter is independent of the nodal distance.
Optimal parameter settings obtained were verified through confirmatory experiments.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com