Sentence examples for optimal milieu from inspiring English sources

However, the adult CNS does not provide an optimal milieu for exogenous NSPCs to survive, engraft, differentiate, and integrate with host tissues.

As [Ca2+]i is an important regulator of downstream signaling, as well as proliferation and differentiation of hMSCs, this observation suggests that specific scale nanotopographies provide an optimal milieu for promoting stem cell mechanotransduction activity.

These data indicate that reduced Cx43 expression contributes to an optimal milieu that facilitates arrhythmogenesis in ARVC.

We deferentially followed the seemingly unassailable logic that normal healthy values would provide the optimal milieu for either maintaining organ function or hastening recovery.

Many studies have shown that a great number of cells die during transplantation and this effect would be diminished if cells were allowed to proliferate in an optimal milieu [ 32, 33].

Stem cells reside in their respective niches [ 29], the distinct anatomical compartments composed of cellular and intercellular matrix constituents providing an optimal milieu for maintenance and regulation of their biologic processes [ 30].

We postulate that post-traumatic pseudolipoma development occurs as a result of inflammatory triggers and an optimal local milieu at the site of development by making an analogy to an in vivo murine tissue engineering model for neo-adipogenesis.

Therefore, transitions within compartments of G1, prior to DNA replication during S phase, may be important for establishing an optimal intracellular milieu for viral infection [47], [61].

On the other hand, nucleosome positioning required for maintenance of the optimal internal milieu in one environment may be far from optimal in a different environment.

These sequences (e.g., the CG variant that is extant in biology today) would have the benefit of long periods of evolutionary optimization in a defined cellular environment where ion transporters could use energy to pump ions against an environmental concentration gradient and create an optimal internal milieu, such as one that is enriched in Mg2+ compared to Ca2+.

Taken together, predominant MR activation during periods of high aldosterone and low cortisol levels seems to provide the optimal endocrine milieu for facilitated homing of naïve T cells to the lymph nodes, i.e., the site where adaptive immune responses are initiated.