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Role-switching biomarkers correspond to features that must, for example, be minimized early, but maximized later, for optimal longevity.
Such a comparison would provide insight into the range of possible outcomes of managed gene flow and refine understanding on the optimal longevity of supportive breeding programs.
They are creating an unprecedented demand for what might be termed optimal longevity —living long, but with an even greater interest in living well.
As such, a key goal for increasing healthspan and achieving optimal longevity must be the preservation of physiological function at the highest possible levels with advancing age.
Together, these conditions are producing an unprecedented demand for increased healthspan or what might be termed "optimal longevity"—to live long, but well.
The optimal longevity and concentration of the enzyme treatment was observed to be 15 min with 5 mg ml−1 collagenase and 5 mg ml−1 dispase (Table 1-wrap>).
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The inevitable biological process of age-related physiological dysfunction leading to increased risk of chronic disease, disability and associated socio-economic consequences, when combined the rapidly changing demographics of aging and new attitudes about growing older, are creating an unprecedented demand for optimal longevity--living long, but with increased healthspan (wellness-fitness).
In general, hormone levels that are optimal for early reproduction are unlikely to also optimize longevity.
But the mouse research has led Dr. Bartke and other gerontologists to a counterintuitive and controversial theory: that having more growth hormone and IGF-1, as Dr. Bartke put it, is "not optimal for longevity".
Public health authorities consider prevention and treatment with nutraceuticals as a powerful instrument in maintaining health and to act against nutritionally induced acute and chronic diseases, thereby promoting optimal health, longevity and quality of life.
Nevertheless, our data agree with the findings of Park and colleagues who concluded that the harmonious interaction of endogenous and environmental rhythms is optimal for longevity, something that was lost in their per1per2 double-null mice (Park et al., 2012).
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