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22 DockScore is an objective scoring scheme that is based on several interface features, and identifies optimal interactions between the interacting proteins in order to find near-native complexes from the pool of docked poses.
The poses obtained subsequent to docking were scored using our scoring scheme DockScore in order to identify the optimal interactions between the putative interacting TFs.
Natural products (NPs) – i.e. secondary metabolites of plants or lower organisms - have been optimized in a very long natural selection process for optimal interactions with biological macromolecules.
In contrast, optimal interactions with cellular attachment factors like the DC-SIGN protein required incorporation of high amounts of GP.
Through the natural selection process, natural products possess a unique and vast chemical diversity and have been evolved for optimal interactions with biological macromolecules.
A machine learning approach (Evo-DoE) could be applied to explore this experimental space and define optimal interactions according to a specific fitness function.
Similar(30)
The genetic clustering of potentially interacting genes could favor their optimal interaction.
The Flat UI design movement, although incorporating subtle elements of 3D, has only reinforced that 2D is the main and most optimal interaction mechanism for existing computing devices.
In a ligand-protein complex very rarely optimal interaction geometries are observed.
The optimal interaction at which translocation is the fastest increases with the concentration of chain on the cis side.
It also allows us to control the excitation mechanism of the RE ions by adjusting the optimal interaction distance between the Si-ncs and the RE ions.
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