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This structure function study indicated that a synergistic role of benzylamide and sulfate substituents resulted in an optimal interaction with the growth factor.
As mentioned before, the normal charging demand is scheduled temporally and the fast charging demand is scheduled spatially, in order to achieve the optimal interaction with DGs and grids.
We individually tailored two components of this drug delivery system for optimal interaction with mucus, designing (1) mucoadhesive fibers for better retention in the vaginal tract, and (2) PEGylated nanoparticles that diffuse quickly through mucus.
While elafin is formed by a single WAP motif and interacted weakly with PLSCR1, SLPI contains two WAP motifs and each motif was able to support binding to PLSCR1, indicating that both domains may cooperate in an additive manner leading to an optimal interaction with PLSCR1.
Our present work on the free Pfu-SRP19 supports the idea that this subunit acts as a molecular scaffold and a chaperone, assisting the SRP RNA in adopting the conformation required for its optimal interaction with the essential subunit SRP54 and thus ensuring the proper maturation and assembly of a functional SRP competent for protein-targeting through the interaction with its cognate receptor.
The efficiency of bacterial translation is known to be under measurable selective pressure; this is evidenced by the fact that, in many bacteria, the most highly expressed genes utilize restricted sets of codons that allow for fast and accurate translation of mRNA, by virtue of their optimal interaction with the most abundant tRNA species for a given amino acid [1] [5].
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Natural products (NPs) – i.e. secondary metabolites of plants or lower organisms - have been optimized in a very long natural selection process for optimal interactions with biological macromolecules.
In contrast, optimal interactions with cellular attachment factors like the DC-SIGN protein required incorporation of high amounts of GP.
Through the natural selection process, natural products possess a unique and vast chemical diversity and have been evolved for optimal interactions with biological macromolecules.
Incorporation of a variety of isosteric groups indicated that appropriate aromatic moieties provide optimal interactions with the hydrophobic and π π interactions with the peripheral anionic site of the AChE active site.
The compound's periphery as well as the overall scaffold geometry was designed to enable optimal interactions with the two distinct sides of the enzyme's active site, one of which is lined with hydrophobic residues and while the other is predominantly hydrophilic.
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