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An interesting example of a nanoparticle 'designed' to activate complement for optimal induction of immune responses.
Thus, IFNβ responsiveness is required in both, the tumour and the host, for optimal induction of anti-tumour immunity by radiation and anti-CTLA4.
Costimulation is an essential component for the optimal induction of T cell-mediated immune responses.
Ossendorp, F., Mengede, E., Camps, M., Filius, R. & Melief, C. J. Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors.
Knocking down p62 in HEK293 cells inhibited the optimal induction of autophagosome formation by not only MG132 but also other various proteasomal inhibitors such as ALLN, bortezomib, and epoxomicin (Fig. 7g; Supplementary Fig. 8f h), further supporting the role of p62 in proteasomal inhibition-induced autophagosome formation.
Optimal induction of NF-κB target genes also requires phosphorylation of NF-κB proteins, such as p65, within their transactivation domain by a variety of kinases in response to distinct stimuli.
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B. subtilis GRSW2-B1, harboring each constructed expression vectors, was grown in LB medium to the same OD600 of approximately 0.8, and induced with the optimal induction condition of each promoter (if necessary) (as described in text).
The optimal induction temperature of 30°C was determined to yield the maximum level of protein expression as shown in Lane 2 of Figure 2A.
The optimal induction treatment of acute myeloid leukemia (AML) in the clinically and biologically heterogeneous group of elderly patients is not well-defined since direct comparisons between treatments is limited.
An intriguing question is what determines the optimal induction levels of stress response systems.
An interesting question to ask is whether there exist optimal induction levels of stress response systems and how these optimal induction levels depend on the characteristics of the microbial habitat.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com